Incidence trends and burden of HPV-associated cancers among women in the US
A study published in Journal of the National Cancer Institute (Aug 2020)
Human papillomavirus (HPV) associated anal and oropharyngeal cancer incidence has increased in recent years among US women. However, trends in incidence and burden (annual number of cases) of non-cervical HPV-associated cancers relative to cervical cancer remain unclear. Using the 2001-2017 US cancer statistics dataset, we evaluated contemporary incidence trends and burden (annual number of cases) of HPV-associated cancers among women by anatomic site, race/ethnicity, and age. Overall, cervical cancer incidence plateaued among White women but continued to decline among Blacks and Hispanics. Anal cancer incidence surpassed cervical cancer incidence among White women aged 65-74 years old (8.6 and 8.2 per 100,000 in 2015) and ≥75 years old (6.2 and 6.0 per 100,000 in 2014). The non-cervical cancer burden (n = 11,871) surpassed the cervical cancer burden (n = 11,527) in 2013. Development of efficacious screening strategies for non-cervical cancers and continued improvement in cervical cancer prevention is needed to combat HPV-associated cancers among women.